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What issue was the most important cause of the split between the eastern and western halves of the Christian church?

AShould a crusade be declared against the Muslim in Palestine?
BSHould Greek or Latin be used in church services?
CShould all religions be tolerated in the empire?
DShould the pope be supreme in church affairs?

Verified Answer :

The issue that was the most important cause of the split between the eastern and western halves of the Christian church was "d. Should the pope be supreme in church affairs?" since this is what divided the Bishops. 

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