"what must occur before a newly made polypeptide is secreted from a cell?

AIt must be translated by a ribosome that remains free within the cytosol

BIts signal sequence must target it to the ER, after which it goes to the Golgi

CIts signal must be cleaved off before the polypeptide can be enter the ER

DIts signal sequence must target it to plasma membrane, where it causes exocytosis