Which of the following will likely result in a misfolded protein (mark all that apply)?

1) Mutation resulting in aberrant STOP codon

2) Mutation in DNA sequence

3) Mutation in splice site

4) Mutation in promoter

I've tried the following combinations, but they are not correct:

1,2,& 4

1 & 4

1,2,3 & 4

1,3 & 4