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Sickle-cell anemia is caused when a mutation results in the replacement of glutamate with valine. Which type of mutation is observed here?


a.chromosomal mutation

b.frameshift mutation

c.substitution mutation

Verified Answer :

oopsydaisy

Out of the following choices, the type of mutation observed is substitution mutation. The correct answer is C.

smilodon

The correct answer is C. Substitution mutation

Substitution mutations are single nucleotide changes in a DNA codon. A codon is a three nucleotide code that gives an information for a specific amino-acid. In this case,the codon was changed from the codon for a valine to a codon for glutamate. This causes a change in the peptide chain that forms the protein.

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