One possible answer is:
9×(2+3)
Explanation:
First we find the sum of 18 and 27. 18+27 = 45.
Next we find the GCF of 18 and 27. We do this by finding the prime factorization of each:
18 = 29
9 = 33
Thus, 18 = 233.
27 = 39
9 = 33
Thus, 27 = 333
We want the common factors; there are 2 3's in common, so 33 = 9 is the GCF. This makes the product 9×( ). The missing number would be 5, since 95 = 45. Writing this as a sum, we can use 2+3; this gives us 9×(2+3).