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Phosphofructokinase is an important control enzyme in the regulation of cellular respiration. Which of the following statements correctly describes phosphofructokinase activity?

AIt is inhibited by AMP.
BIt is activated by ATP.
CIt is activated by citrate, an intermediate of the citric acid cycle.
DIt catalyzes the conversion of fructose 1,6-bisphosphate to fructose 6-phosphate, an early step of glycolysis.
EIt is an allosteric enzyme.

Verified Answer :

JcAlmighty

The answer is E) It is an allosteric enzyme.

Phosphofructokinase changes it conformational ensemble when is bound to an effector.  This suggests that it is an allosteric enzyme.  It is activated by AMP, and inhibited by ATP and citrate. It catalyzes the conversion of fructose 6-phosphate to fructose 1,6-bisphosphate.

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