Drugs that have a significant first-pass effect:
1.Must be given by the enteral (oral) route only
2.Bypass the hepatic circulation
3.Are rapidly metabolized by the liver and may have little if any desired action
4.Are converted by the liver to more active and fat-soluble forms
1.Must be given by the enteral (oral) route only
2.Bypass the hepatic circulation
3.Are rapidly metabolized by the liver and may have little if any desired action
4.Are converted by the liver to more active and fat-soluble forms