Through which of the following mechanisms, a protein can accumulate in the nucleus?
1. strongly interacting with an ER membrane protein
2. directly interacting with Phe-Gly (FG) repeats of in the nuclear pore complexes
3. a nuclear localization signal (NLS)-mediated protein import
4. containing an amphipathic helix associated with the plasma membrane
1. strongly interacting with an ER membrane protein
2. directly interacting with Phe-Gly (FG) repeats of in the nuclear pore complexes
3. a nuclear localization signal (NLS)-mediated protein import
4. containing an amphipathic helix associated with the plasma membrane