What is the effect of defective or missing N-acetylglucosamine phosphotransferase on lysosomal protein sorting?
a. Lysosmal proteins are secreted from the cell.
b. Lysosomal proteins remain bound to M6P receptors
c. Nonfunctional lysosomal hydrolases accumulate in lysosomes
d. Lysosomal proteins are retained in the ER
e. Lysosomal proteins are retained in the Golgi network